Differences between bone mineral density, lean and fat mass of HIV-positive and HIV-negative black women

  • C Ellis North-West University
  • H S Kruger North-West University
  • P Ukegbu North-West University
  • I M Kruger North-West University
  • M Viljoen University of the Western Cape
  • M C Kruger Massey University
Keywords: black women, bone mineral density, fat mass, HIV, lean mass

Abstract

Objectives: To investigate the differences between bone mineral density (BMD), lean and fat mass of human immunodeficiency virus (HIV-) positive and HIV-negative black women and to investigate factors associated with low BMD.

Methods: Case-control study of black women (n = 565) aged 29–65 years from Potchefstroom, North West province, South Africa, based on secondary analysis of data. Total BMD, left femur neck of the hip (LFN BMD), spine BMD, total fat, fat-free tissue mass and percentage body fat (%BF) were measured by dual-energy X-ray absorptiometry.

Results: HIV-negative women had significantly higher median BMD, %BF, appendicular skeletal mass (ASM), ASM index, body mass index (BMI) and waist circumference than HIV-positive women. When the groups were matched for age and BMI, only spine BMD was marginally lower in HIV-positive women. In the total group, age, smoking and HIV status were associated with lower BMD, while calcium intake was positively associated with BMD. Similar variables were associated with BMD in HIV-negative women, while age and educational status were associated with BMD in HIV-positive women. 

Conclusion: Low BMD was more common among HIV-positive than HIV-negative women. Older HIV-positive women with low educational status are particularly at risk.

The full article is available at https://doi.org/10.1080/16089677.2019.1589047

Author Biographies

C Ellis, North-West University

Centre of Excellence for Nutrition, North-West University, Potchefstroom, South Africa

H S Kruger, North-West University

Centre of Excellence for Nutrition, North-West University, Potchefstroom and Medical Research Council Hypertension and Cardiovascular Disease Research Unit, North-West University, Potchefstroom, South Africa

P Ukegbu, North-West University

aentre of Excellence for Nutrition, North-West University, Potchefstroom, South Africa

I M Kruger, North-West University

Africa Unit for Transdisciplinary Health Research, North-West University, Potchefstroom, South Africa

M Viljoen, University of the Western Cape

Department of Pharmacology and Clinical Pharmacy, University of the Western Cape, Bellville, South Africa

M C Kruger, Massey University

School of Health Sciences, Massey University, Palmerston North, New Zealand

Published
2019-07-23
Section
Research Articles