Characteristics of subjects with diabetes mellitus diagnosed before 35 years of age presenting to a tertiary diabetes clinic in Durban, South Africa, from 2003 to 2016

  • Prevendri Govender University of KwaZulu-Natal
  • Khaled Elmezughi University of KwaZulu-Natal
  • Tonya Esterhuizen University of KwaZulu-Natal
  • Imran Paruk University of KwaZulu-Natal
  • Fraser James Pirie University of KwaZulu-Natal
  • Ayesha Ahmed Motala University of KwaZulu-Natal
Keywords: diabetes in youth, South Africa

Abstract

Background: Most patients diagnosed with diabetes mellitus < 35 years will have type 1 diabetes (T1D). The increase in youth-onset type 2 diabetes (T2D) parallels the obesity epidemic and in African subjects ketosis-prone type 2 diabetes (KPD) may occur in this age group. Objectives, setting and subjects: To evaluate the clinical, biochemical and immunologic characteristics of patients diagnosed with diabetes < 35 years presenting to a tertiary diabetes clinic in Durban, South Africa over 13 years. Design: A retrospective chart review of patients < 35 years diagnosed with diabetes was conducted. Data included clinical and laboratory variables, complications and follow-up status. Results: The study included 517 patients of whom 445 (86.1%) were diagnosed with T1D, 27 (5.2%) with T2D, 27 with KPD (5.2%) and 18 (3.5%) with other forms of diabetes. Mean age of the total group was 28 ± 10 years. Subjects with T1D were younger at diagnosis with a lower BMI than both T2D and KPD. HbA1c was higher in subjects with T1D. Overall mortality was low (3.5%) and follow-up was poor in all groups. Conclusion: The majority of young people with diabetes in KwaZulu-Natal, South Africa, have T1D, with small numbers of other types. Glucose control is poor with a high loss to follow-up. (Full text available online at www.medpharm.tandfonline.com/oemd) Journal of Endocrinology, Metabolism and Diabetes of South Africa 2018; DOI: 10.1080/16089677.2017.1417779

Author Biographies

Prevendri Govender, University of KwaZulu-Natal
Department of Diabetes and Endocrinology Nelson R Mandela School of Medicine University of KwaZulu-Natal Durban
Khaled Elmezughi, University of KwaZulu-Natal
Department of Diabetes and Endocrinology Nelson R Mandela School of Medicine University of KwaZulu-Natal Durban
Tonya Esterhuizen, University of KwaZulu-Natal
Department of Diabetes and Endocrinology Nelson R Mandela School of Medicine University of KwaZulu-Natal Durban
Imran Paruk, University of KwaZulu-Natal
Department of Diabetes and Endocrinology Nelson R Mandela School of Medicine University of KwaZulu-Natal Durban
Fraser James Pirie, University of KwaZulu-Natal
Department of Diabetes and Endocrinology Nelson R Mandela School of Medicine University of KwaZulu-Natal Durban
Ayesha Ahmed Motala, University of KwaZulu-Natal
Department of Diabetes and Endocrinology Nelson R Mandela School of Medicine University of KwaZulu-Natal Durban
Published
2018-05-21
Section
Research Articles