Obesity and kidney disease: hidden consequences of the epidemic

  • Csaba P Kovesdy University of Tennessee Health Science
  • Susan Furth University of Pennsylvania
  • Carmine Zoccali
Keywords: obesity, kidney disease


Obesity has become a worldwide epidemic, and its prevalence has been projected to grow by 40% in the next decade. This increasing prevalence has implications for the risk of diabetes, cardiovascular disease and also for chronic kidney disease. A high body mass index is one of the strongest risk factors for new-onset chronic kidney disease. In individuals affected by obesity, a compensatory hyperfiltration occurs to meet the heightened metabolic demands of the increased bodyweight. The increase in intraglomerular pressure can damage the kidneys and raise the risk of developing chronic kidney disease in the long term. The incidence of obesity-related glomerulopathy has increased tenfold in recent years. Obesity has also been shown to be a risk factor for nephrolithiasis, and for a number of malignancies including kidney cancer. This year World Kidney Day promotes education on the harmful consequences of obesity and its association with kidney disease, advocating a healthy lifestyle and health policy measures that makes preventive behaviours an affordable option. (Full text available online at www.medpharm.tandfonline.com/oemd) Journal of Endocrinology, Metabolism and Diabetes of South Africa 2017; DOI: 10.1080/16089677.2017.1299975

Author Biographies

Csaba P Kovesdy, University of Tennessee Health Science
Division of Nephrology Department of Medicine University of Tennessee Health Science Center; and Nephrology Section Memphis VA Medical Center Tennessee United State of America
Susan Furth, University of Pennsylvania
Department of Pediatrics Perelman School of Medicine University of Pennsylvania Philadelphia
Carmine Zoccali
CNR – IFC Clinical Epidemiology and Pathophysiology of Renal Diseases and Hypertension Reggio Calabria Italy
Original Research