Investigating the effects of <i>Lactobacillus casei</i> on some biochemical parameters in diabetic mice

  • Feizollah Asgharzadeh Tabriz University of Medical Sciences
  • Asghar Tanomand Maragheh University of Medical Sciences
  • Mohammad Reza Ashoori Tabriz University of Medical Sciences
  • Ali Asgharzadeh Iran University of Medical Sciences
  • Nosratollah Zarghami Tabriz University of Medical Sciences
Keywords: diabetes, Lactobacillus casei, probiotic

Abstract

Aims: Diabetes mellitus is a metabolic disorder characterised by inadequate pancreatic insulin secretion or the insulin present being unable to perform its function properly. Consistent with the beneficial effects of probiotics and their ability to lower glucose levels, an impact on diabetes treatment is also expected. The aim of this study was to evaluate the effect of Lactobacillus casei on various either biochemical parameters in a diabetic mice model. Methods: In the present study, 24 mice were divided into diabetic and control groups. Further, each group was categorised into two subgroups. The diabetic and control subgroups were fed carrot juice or Lactobacillus casei in carrot juice. Diabetes was induced by streptozotocin (STZ). For 30 days, the mice were fed 2 ml carrot juice, and Lactobacillus casei in carrot juice (with lactobacillus 109 cfu/ml) by gavage. Then, blood samples were collected to assay biochemical parameters. Results: The results of this study showed that Lactobacillus casei (ATCC39392) significantly reduced blood glucose (BG) levels in diabetic mice receiving the probiotic, but did not cause a significant change in BG levels in control mice receiving the probiotic. When comparing insulin, insulin-like growth factor I (IGF-I) and C-peptide in the four groups, it was found that insulin and C-peptide were significantly different in all groups except for the control group treated with a mixture of probiotic Lactobacillus casei and carrot juice. Conclusion: Our results showed that probiotic Lactobacillus casei effectively reduces BG levels in diabetic mice treated with this bacterium. (Full text available online at www.medpharm.tandfonline.com/oemd) Journal of Endocrinology, Metabolism and Diabetes of South Africa 2017; DOI: 10.1080/16089677.2017.1378460

Author Biographies

Feizollah Asgharzadeh, Tabriz University of Medical Sciences
Faculty of Medicine Department of Clinical Biochemistry and Laboratory Sciences Tabriz University of Medical Sciences Tabriz
Asghar Tanomand, Maragheh University of Medical Sciences
Department of Microbiology Maragheh University of Medical Sciences Maragheh
Mohammad Reza Ashoori, Tabriz University of Medical Sciences
Faculty of Medicine Department of Clinical Biochemistry and Laboratory Sciences Tabriz University of Medical Sciences Tabriz
Ali Asgharzadeh, Iran University of Medical Sciences
Tehran Institute of Psychiatry Iran University of Medical Sciences Tehran
Nosratollah Zarghami, Tabriz University of Medical Sciences
Faculty of Medicine Department of Clinical Biochemistry and Laboratory Sciences Tabriz University of Medical Sciences Tabriz
Published
2017-12-04
Section
Research Articles