SEMDSA/ACE-SA Guideline for the Management of Hypothyroidism in Adults

  • Joel Dave University of Cape Town
  • Ania Klisiewicz
  • Zaheer Bayat University of the Witwatersrand
  • Nazeer Ahmed Mohamed University of the Witwatersrand
  • Zane Stevens
  • Willem F Mollentze University of the Free State
  • Tanya Kinvig
Keywords: hypothyroidism, SA Guidelines, management, adults

Abstract

Background: Hypothyroidism is a common clinical condition confronting all healthcare practitioners yet there remains uncertainty about the optimal medication and optimum treatment targets. In addition, many patients remain symptomatic despite using recommended medications and attaining recommended treatment targets. Methods: All endocrinologists in South Africa who consented to be part of the guideline process were assigned various aspects of the management of patients with thyroid disease. In each section the current literature was reviewed and the level of evidence was graded. This information was then presented at a guideline meeting. Where evidence was lacking a consensus among participants was adopted. Results: This guideline provides 11 recommendations for the management of primary hypothyroidism, secondary hypothyroidism and subclinical hypothyroidism in adults. Conclusions: This is the first South African guideline for the management of hypothyroidism in adults and represents a comprehensive review of the current literature in an attempt to provide evidence-based guidance for all healthcare practitioners regarding the many clinical aspects encountered when managing patients with hypothyroidism.

Author Biographies

Joel Dave, University of Cape Town
FCP (SA) PhD Division of Diabetic Medicine and Endocrinology Department of Medicine University of Cape Town South Africa
Ania Klisiewicz
FCP (SA) MMed Private Practice Johannesburg South Africa
Zaheer Bayat, University of the Witwatersrand
FCP (SA) Division of Endocrinology Department of Medicine University of the Witwatersrand South Africa
Nazeer Ahmed Mohamed, University of the Witwatersrand
FCP (SA) Division of Endocrinology Department of Medicine University of the Witwatersrand South Africa
Zane Stevens
FCP (SA) MMed Private Practice Cape Town South Africa
Willem F Mollentze, University of the Free State
LKI (SA) MMed (Int) Emeritus Professor of Medicine Manager of the Christo Strydom Metabolic Research Unit University of the Free State
Tanya Kinvig
FCP (SA) Private Practice Cape Town South Africa
Section
Guidelines