Relationship between MPV and paraoxonase-1 activity, brachial artery diameter and IMT in patients with diabetes mellitus

  • Pınar Karakaya Bakırköy Sami Konu Training and Research Hospital
  • Yıldız Okuturlar Bakirkoy Dr Sadi Konuk Training and Research Hospital
  • Meral Mert Bakirkoy Dr. Sadi Konuk Training and Research Hospital
  • Asuman Gedikbaşı Bakirkoy Dr Sadi Konuk Training and Research Hospital
  • Filiz İslim Bakirkoy Dr Sadi Konuk Training and Research Hospital
  • Didem Acarer Bakirkoy Dr Sadi Konuk Training and Research Hospital
  • Nursel Kocamaz Bakirkoy Dr Sadi Konuk Training and Research Hospital
  • Ozlem Soyluk Bakirkoy Dr Sadi Konuk Training and Research Hospital
  • Teslime Ayaz Recep Tayyip Erdogan University Training and Research Hospital
  • Pınar Alarslan Katip Celebi University Ataturk Training and Research Hospital
  • Ozlem Harmankaya Bakirkoy Dr Sadi Konuk Training and Research Hospital
  • Abdulbaki Kumbasar Bakirkoy Dr Sadi Konuk Training and Research Hospital
Keywords: Diabetes, obesity, cardiovascular, vasculature, insulin resistance

Abstract

Aims: Higher mean platelet volume (MPV) in diabetic patients has been considered as an emerging risk factor for diabetes related micro- and macrovascular complications. Human paraoxonase 1/arylesterase (PON1), which has antioxidant and antiatherogenic properties, is documented in high oxidative stress conditions like uncontrolled diabetes. The present study aimed to evaluate the relationship between mean platelet volume (MPV) and paraoxonase-1 (PON-1) activity, brachial artery diameter (BAd) and intima media thickness (BA-IMT), in diabetic patients with regard to obesity and diabetic complications. Methods: Two-hundred and one diabetic patients (mean age: 52.4 ± 13.4 years, 73.6% females) were grouped according to obesity and diabetic complications (microvascular and macrovascular). Data on demographics, anthropometrics, diabetic complications, MPV levels, BAd and BA-IMT, and serum paraoxonase and arylesterase activities were recorded. The correlation of MPV values to paraoxonase and arylesterase activities, BAd and BA-IMT was evaluated. Results: Paraoxonase and arylesterase values were 119.8 ± 37.5 U/L and 149.0 ± 39.9 U/L, respectively, with no significant difference in respect of obesity and macrovascular complications. Significantly lower values for paraoxonase (107.5 ± 30.7 vs. 123.9 ± 38.8 U/L, p = 0.007) and arylesterase (132.1 ± 30.2 vs. 154.7 ± 41.2, U/L, p = 0.001) were noted in patients with microvascular complications. MPV values were 9.10 ± 0.87 fL, with no significant difference across the groups and no significant correlation with other parameters. Conclusion: In conclusion, PON-1 activity is more significantly decreased in diabetic patients with microvascular than macrovascular complications with no effects on MPV values. On the other hand, no relationship was found between thrombogenic activity and PON-1 activity, BAd and BA-IMT regardless of obesity and diabetic complications. (Full text available online at www.medpharm.tandfonline.com/oemd) Journal of Endocrinology, Metabolism and Diabetes of South Africa 2016; DOI: 10.1080/16089677.2016.1212964

Author Biographies

Pınar Karakaya, Bakırköy Sami Konu Training and Research Hospital
Department of Endocrinology Bakirkoy Dr Sadi Konuk Training and Research Hospital
Yıldız Okuturlar, Bakirkoy Dr Sadi Konuk Training and Research Hospital
Department of Internal Medicine, Bakirkoy Dr Sadi Konuk Training and Research Hospital
Meral Mert, Bakirkoy Dr. Sadi Konuk Training and Research Hospital
Department of Endocrinology Bakirkoy Dr Sadi Konuk Training and Research Hospital
Asuman Gedikbaşı, Bakirkoy Dr Sadi Konuk Training and Research Hospital
Department of Biochemistry Bakirkoy Dr Sadi Konuk Training and Research Hospital
Filiz İslim, Bakirkoy Dr Sadi Konuk Training and Research Hospital
Department of Radiology Bakirkoy Dr Sadi Konuk Training and Research Hospital
Didem Acarer, Bakirkoy Dr Sadi Konuk Training and Research Hospital
Department of Internal Medicine Bakirkoy Dr Sadi Konuk Training and Research Hospital
Nursel Kocamaz, Bakirkoy Dr Sadi Konuk Training and Research Hospital
Department of Internal Medicine Bakirkoy Dr Sadi Konuk Training and Research Hospital
Ozlem Soyluk, Bakirkoy Dr Sadi Konuk Training and Research Hospital
Department of Endocrinology Bakirkoy Dr Sadi Konuk Training and Research Hospital
Teslime Ayaz, Recep Tayyip Erdogan University Training and Research Hospital
Department of Internal Medicine Recep Tayyip Erdogan University Training and Research Hospital
Pınar Alarslan, Katip Celebi University Ataturk Training and Research Hospital
Department of Endocrinology Katip Celebi University Ataturk Training and Research Hospital
Ozlem Harmankaya, Bakirkoy Dr Sadi Konuk Training and Research Hospital
Department of Internal Medicine Bakirkoy Dr Sadi Konuk Training and Research Hospital
Abdulbaki Kumbasar, Bakirkoy Dr Sadi Konuk Training and Research Hospital
Departmentg of Internal Medicine Bakirkoy Dr Sadi Konuk Training and Research Hospital
Published
2016-11-29
Section
Research Articles