Telangiectatic osteosarcoma, a rare complication of Paget’s disease of bone

  • Francois Hayward van Zyl Stellenbosch University
  • Magda Conradie Stellenbosch University
  • Karen Barnard Stellenbosch University
  • Stephen Hough Stellenbosch University
  • Brynne H Ascott-Evans Stellenbosch University
Keywords: Paget’s disease of Bone, Telangiectatic Osteosarcoma

Abstract

Paget’s disease of bone (PDB) is the second most common metabolic bone disease. This condition, characterised by abnormal bone remodelling, has a prevalence of 5-8% in patients of European ancestry over the age of 55 years.1-4 The majority of patients are asymptomatic. Diagnosis is based on the distinct radiological picture or on the elevation of serum alkaline phosphatase (ALP). Malignant sarcomatous degeneration is a rare (< 1%) and often fatal complication of PDB.5-8 Osteosarcoma is considered to be a rare and devastating complication of PDB. We report on a confirmed case of very rare telangiectatic osteosarcoma in monostotic PDB.

Author Biographies

Francois Hayward van Zyl, Stellenbosch University
BMedSc, MBChB,MMed(Int) Fellow Division of Endocrinology Department of Medicine Tygerberg Academic Hospital Stellenbosch University Cape Town
Magda Conradie, Stellenbosch University
MBChB, PhD Consultant Division of Endocrinology Department of Medicine Tygerberg Academic Hospital Stellenbosch University Cape Town
Karen Barnard, Stellenbosch University
MBChB, MPH Consultant Division of Endocrinology Department of Medicine Tygerberg Academic Hospital Stellenbosch University Cape Town
Stephen Hough, Stellenbosch University
MBChB, Hons Bsc, FCP(SA), MMed, MD Consultant Division of Endocrinology Department of Medicine Tygerberg Academic Hospital Stellenbosch University Cape Town
Brynne H Ascott-Evans, Stellenbosch University
MBChB, FCP(SA) Head Division of Endocrinology Department of Medicine Stellenbosch University Cape Town
Published
2014-02-19
Section
Case Study