Leptin: a cardiovascular perspective

  • Alta Schutte North-West University
  • Rudolph Schutte North-West University
Keywords: adipokine, obesity, cardiovascular, leptin

Abstract

The development of obesity, as well as resultant type 2 diabetes, hypertension and cardiovascular disease, is causing concern in South Africa. Following the discovery of leptin in 1994, hopes were raised that the manipulation of the leptin axis might yield successful therapy for obesity. Although hope still remains, the role of leptin is more complex than was first envisaged. Strong evidence indicates that there is an important role for leptin in obesityrelated hypertension, although the net effects of hyperleptinaemia on cardiovascular pathophysiology remain complex and are not clearly understood. Therefore, the cardiovascular side-effects of leptin as a possible antiobesity drug deserve greater attention.

Author Biography

Rudolph Schutte, North-West University
Hypertension in Africa Research Team (HART) North-West University (Potchefstroom Campus)
Published
2012-08-01
Section
Review Articles