Pulmonary hypertension and thyrotoxicosis

  • Marli Conradie University of Stellenbosch
  • C Koegelenberg University of Stellenbosch
  • M Conradie University of Stellenbosch
  • B H Ascott- Evans University of Stellenbosch
  • F S Hough University of Stellenbosch
Keywords: Thyrotoxicosis, Hyperthyroidism, Pulmonary Hypertension

Abstract

Thyrotoxicosis is listed as a cause of pulmonary arterial hypertension (PAH). The aetiopathogenesis remains largely uncertain, but an autoimmune mechanism has been postulated, among others. In this setting, other causes of PAH need to be actively sought and excluded prior to attributing it to the thyrotoxicosis. The importance of recognising this condition is that it is usually reversible with restoration of a euthyroid state. We describe three patients who presented with thyrotoxicosis and features of PAH in whom other causes were excluded with various investigations. We also demonstrated reversibility of the pulmonary hypertension upon restoration of a normal thyroid state.

Author Biographies

Marli Conradie, University of Stellenbosch
MBChB, MMed, FCP(SA), Cert Endo and Metab (SA)-Physicians Senior Registrar Division of Endocrinology and Metabolism Department of Medicine University of Stellenbosch
C Koegelenberg, University of Stellenbosch
MBChB, MMed, FCP(SA), Cert Pulmonol (SA)-Physicians, PhD Divisions of Pulmonology Department of Medicine University of Stellenbosch
M Conradie, University of Stellenbosch
MBChB, PhD Division of Endocrinology and Metabolism Department of Medicine University of Stellenbosch
B H Ascott- Evans, University of Stellenbosch
MBChB, FCP(SA) Division of Endocrinology and Metabolism Department of Medicine University of Stellenbosch
F S Hough, University of Stellenbosch
MBChB, Hons BSc, FCP(SA), MMed, MD(Stell) Division of Endocrinology and Metabolism Department of Medicine University of Stellenbosch
Published
2012-08-01
Section
Case Study