Insulin resistance induced by antiretroviral drugs: Current understanding of molecular mechanisms

  • W I W Ismail University of Cape Town and National Health Laboratory Service
  • J A King University of Cape Town and National Health Laboratory Service
  • Tahir S Pillay University of Cape Town
Keywords: HIV protease inhibitors, insulin resistance, insulin signalling pathway

Abstract

The increase in incidence of HIV infection continues to be a major public health problem across the world, but more especially in sub-Saharan Africa. Treatment with highly active antiretroviral therapy (HAART) has improved the prognosis of patients with AIDS, but it has also increased the incidence of various metabolic disorders, in particular insulin resistance accompanied by dyslipidaemia, hyperglycaemia and lipodystrophy. This is often accompanied by frank type 2 diabetes and increased mortality from cardiovascular disease. It is important to understand the mechanistic basis for these side-effects as the incidence of these is likely to increase as the rollout of antiretroviral drugs continues.

Author Biographies

W I W Ismail, University of Cape Town and National Health Laboratory Service
BSc (Hons), MSc Division of Chemical Pathology Department of Clinical Laboratory Sciences University of Cape Town and National Health Laboratory Service Groote Schuur Hospital, Cape Town, 7925, South Africa
J A King, University of Cape Town and National Health Laboratory Service
BSc (Hons), MSc, PhD Division of Chemical Pathology Department of Clinical Laboratory Sciences University of Cape Town and National Health Laboratory Service Groote Schuur Hospital, Cape Town, 7925, South Africa
Tahir S Pillay, University of Cape Town
MBChB, PhD, FRCPath (UK), FCPath (SA) Chief Specialist, Professor and Head Division of Chemical Pathology University of Cape Town
Published
2009-11-15
Section
Review Articles